Zoonotic diseases are animal diseases that can be transmitted to humans. GALVmed works on neglected zoonotic diseases that have severe constraints on small-scale agriculture in Africa and South Asia. These diseases are: Brucellosis, Porcine Cysticercosis, Rift Valley Fever.

Vector-borne zoonotic diseases are becoming a major public health concern. In fact, scientists estimate that more than 6 out of every 10 infectious diseases in humans are spread from animals. Emerging Infectious Disease outbreaks have risen rapidly over the last decade and are a major cost to the global economy. As stated in a Nature journal article titled “Global trends in emerging infectious diseases”, “The main source of EIDs is zoonotic transmission, accounting for 60 percent of all outbreaks.”

At GALVmed, we work with partners to provide affordable and accessible animal health products, vaccines and diagnostics to the millions of those who rely on livestock as a lifeline in Africa and South Asia. We do this through research and development; commercial development; policy and advocacy.

• Rift Valley Fever and Trypanosomosis
• Brucellosis
• Porcine Cysticercosis

Videos, blog articles, news, and peer-reviewed publications on GALVmed’s zoonotic diseases work.

• Breaking the cycle of the zoonotic disease Neurocysticercosis
• We need a game-changer for combating zoonotic diseases
• Smart partnerships to eradicate zoonotic diseases
• Controlling zoonotic diseases requires coordinated efforts
• A tale of two states: How a zoonotic disease can be transmitted to unsuspecting consumers
• Seeking the Next Generation of Livestock Trypanocides
• World Zoonoses Day: Spotlight on the most common zoonotic disease

• New tools to tackle porcine cysticercosis in rural Uganda

• Tackling the major cause of epilepsy in the developing world

Porcine Cysticercosis

• A market scoping study for porcine cysticercosis vaccine calls for a one-health approach to sustain the control of the disease in Uganda (2019)
• Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal (2019)
• Accurate diagnosis of lesions suspected of being caused by Taenia solium in body organs of pigs with naturally acquired porcine cysticercosis (2019)
• Taenia solium from a community perspective: Preliminary costing data in the Katete and Sinda districts in Eastern Zambia (2018)
• Re-visiting the detection of porcine cysticercosis based on full carcass dissections of naturally Taenia solium infected pigs (2017)
• A hyperendemic focus of Taenia solium transmission in the Banke District of Nepal (2017)
• Oxfendazole flukicidal activity in pigs (2014)
• Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs. (2013)
• A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles (2012)

Rift Valley Fever

• Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine (2020)
• Vaccination for the Control of Rift Valley Fever in Enzootic and Epizootic Situations (2013)

Trypanosomosis

• The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing (2018)
• Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT) (2017)
• Assessment of Animal African Trypanosomiasis vulnerability in cattle-owning communities of sub-Saharan Africa (2016)
• Proteomic Identification of Immunodiagnostic Antigens for Trypanosoma vivax Infections in Cattle and Generation of a Proof-of-Concept Lateral Flow Test Diagnostic Device (2016)
• Burkina Faso Field Study Report on Animal African Trypanosomosis (2016)
• Cameroon Field Study Report on Animal African Trypanosomosis (2016)
• Ethiopia Field Study Report on Animal African Trypanosomosis (2016)
• Uganda Field Study Report on Animal African Trypanosomosis (2016)
• Zambia Field Study Report on Animal African Trypanosomosis (2016)
• AN11736, A Benzoxaborole Clinical Candidate for Treatment of T.congolense and T. vivax African Animal Trypanosomosis (2016)
• Past and Ongoing Tsetse and Animal Trypanosomiasis Control Operations in Five African Countries: A Systematic Review (2016)
• Development and evaluation of an ITS1 “Touchdown” PCR forassessment of drug efficacy against animal African trypanosomosis (2014)
• Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense. (2014)
• Trypanosoma vivax GM6 Antigen: A Candidate Antigen for Diagnosis of African Animal Trypanosomosis in Cattle (2013)
• Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes (2013)
• Community- and farmer-based management of animal African trypanosomosis in cattle (2013)
• Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during Trypanosoma vivax infection. (2013)
• Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake (2012)

• GALVmed brucellosis vaccine project begins to result in R&D advancements
• GALVmed: Success of brucellosis vaccine innovation could be replicated for other diseases
• First registered vaccine for porcine cysticercosis nears sale in India
• Indian Firm to Launch World’s First Pig Vaccine for Cysticercosis
• Of pigs and people – WHO prepares to battle cysticercosis