Home News General Trypanosomosis

Trypanosomosis, also known as Tsetse Disease, is transmitted by the bite of the tsetse fly. Affecting both domestic and wild animals, trypanosomosis is found wherever in the world the tsetse fly exists, including Africa, South and Central America.

Humans can also contract trypanosomosis from insect bites.

The severity of the disease varies with species and age of the infected animal and the species of the tsetse fly involved. The incubation period ranges from is usually 1 to 4 weeks and the primary symptoms are intermittent fever, anemia, and weight loss. Cattle usually have a chronic course with high mortality, especially if there is poor nutrition or other stress factors.

Several drugs can be used for treatment, though most have a narrow therapeutic index, which makes administration of the correct dose essential and, after repeated doses for stubborn cases, drug resistance can occur.

Control can be exercised at several levels, including eradication of tsetse flies and use of prophylactic drugs. Tsetses can be partially controlled by frequent spraying and dipping of animals, spraying of insecticides on fly-breeding areas, use of insecticide-impregnated screens, bush clearing, and other methods. Animals can be given drugs prophylactically in areas with a high population of trypanosome-infected tsetse.

There is currently no vaccine available for trypanosomosis

The GALVmed Trypanocide Compound Progression Criteria can be viewed/downloaded from here.

Target Product Profiles downloads

The following are links to some of the papers that have been published under the Trypanosomosis Phase 1 programme;

  1. http://www.sciencedirect.com/science/article/pii/S0304401714001526
  2. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0078565
  3. http://www.sciencedirect.com/science/article/pii/S2211320713000055
  4. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003710
  5. https://www.cell.com/trends/parasitology/abstract/S1471-4922(13)00137-2
  6. http://onlinelibrary.wiley.com/doi/10.1111/cmi.12123/abstract;jsessionid=0E6E3A45317A254792FE8C35A548DD93.f04t01